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punctata aerial parts, administered at 2,000 mg/kg, showed no significant changes in behavior or mortality in mice

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Cellular capacities for ROS elimination are limited in Nrf2 -null mice ( Nrf2 -null mice tend to spontaneously develop various inflammatory disorders, including glomerulonephritis, immune-mediated hemolytic anemia, and multi-organ autoimmune inflammation (Yoh et al., 2001

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The mechanism involves a muscle-brain communication pathway